全文获取类型
收费全文 | 40901篇 |
免费 | 729篇 |
国内免费 | 184篇 |
专业分类
系统科学 | 1205篇 |
丛书文集 | 534篇 |
教育与普及 | 70篇 |
理论与方法论 | 390篇 |
现状及发展 | 17141篇 |
研究方法 | 1481篇 |
综合类 | 20460篇 |
自然研究 | 533篇 |
出版年
2018年 | 770篇 |
2017年 | 808篇 |
2016年 | 555篇 |
2012年 | 733篇 |
2011年 | 1938篇 |
2010年 | 1011篇 |
2009年 | 612篇 |
2008年 | 1120篇 |
2007年 | 1545篇 |
2006年 | 665篇 |
2005年 | 700篇 |
2004年 | 770篇 |
2003年 | 818篇 |
2002年 | 711篇 |
2001年 | 1143篇 |
2000年 | 1079篇 |
1999年 | 761篇 |
1994年 | 369篇 |
1992年 | 729篇 |
1991年 | 544篇 |
1990年 | 620篇 |
1989年 | 612篇 |
1988年 | 560篇 |
1987年 | 650篇 |
1986年 | 594篇 |
1985年 | 758篇 |
1984年 | 603篇 |
1983年 | 480篇 |
1982年 | 435篇 |
1981年 | 453篇 |
1980年 | 546篇 |
1979年 | 1115篇 |
1978年 | 929篇 |
1977年 | 880篇 |
1976年 | 751篇 |
1975年 | 784篇 |
1974年 | 983篇 |
1973年 | 879篇 |
1972年 | 919篇 |
1971年 | 1020篇 |
1970年 | 1308篇 |
1969年 | 990篇 |
1968年 | 997篇 |
1967年 | 937篇 |
1966年 | 864篇 |
1965年 | 593篇 |
1959年 | 311篇 |
1958年 | 539篇 |
1957年 | 358篇 |
1956年 | 304篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
92.
The exponential Radon transform, a generalization of the Radon transform, is defined and studied as a mapping of function
spaces. It is represented in terms of Fourier transform of its domain and range, and this leads to the harmonic decomposition
reconstruction. The results are similar results of Tretiak and Metz.
Foundation item: Supported by the National Natural Science Foundation of China (No. 19971064), Key Project of Science and
Technology of Hubei Province Education Committee.
Biography: Wang Jin-ping (1963-), male, Ph.D. candidate, research direction: numberical solution of singular integral equation
and integral transformation etc. 相似文献
93.
YU Jianqiao LIAO Jianwei 《武汉大学学报:自然科学英文版》2007,12(5):887-892
We propose a multiple-tree overlay structure for resource discovery in unstructured P2P systems. Peers that have similar interests or hold similar type of resources will be grouped into a tree-like cluster. We exploit the heterogeneity of peers in each cluster by connecting peers with more capacities closer to the root of the tree. The capacity of a peer can be defined in different ways (e.g. higher network bandwidth, larger disk space, more data items of a certain type etc.) according to different needs of users or applications. 相似文献
94.
Edouard T Montagner A Dance M Conte F Yart A Parfait B Tauber M Salles JP Raynal P 《Cellular and molecular life sciences : CMLS》2007,64(13):1585-1590
Activating and inactivating mutations of SHP-2 are responsible, respectively, for the Noonan (NS) and the LEOPARD (LS) syndromes.
Clinically, these developmental disorders overlap greatly, resulting in the apparent paradox of similar diseases caused by
mutations that oppositely influence SHP-2 phosphatase activity. While the mechanisms remain unclear, recent functional analysis
of SHP-2, along with the identification of other genes involved in NS and in other related syndromes (neurofibromatosis-1,
Costello and cardio-facio-cutaneous syndromes), strongly suggest that Ras/MAPK represents the major signaling pathway deregulated
by SHP-2 mutants. We discuss the idea that, with the exception of LS mutations that have been shown to exert a dominant negative
effect, all disease-causing mutations involved in Ras/MAPK-mediated signaling, including SHP-2, might lead to enhanced MAPK
activation. This suggests that a narrow range of MAPK signaling is required for appropriate development. We also discuss the
possibility that LS mutations may not simply exhibit dominant negative activity.
Received 30 November 2006; received after revision 8 February 2007; accepted 13 March 2007 相似文献
95.
Crnković-Mertens I Wagener N Semzow J Gröne EF Haferkamp A Hohenfellner M Butz K Hoppe-Seyler F 《Cellular and molecular life sciences : CMLS》2007,64(9):1137-1144
Cancer cells are typically characterized by apoptosis deficiency. In order to investigate a possible role for the anti-apoptotic
livin gene in renal cell cancer (RCC), we analyzed its expression in tumor tissue samples and in RCC-derived cell lines. In addition,
we studied the contribution of livin to the apoptotic resistance of RCC cells by RNA interference (RNAi). Livin gene expression was detected in a significant portion of RCC tumor tissue specimens (13/14, 92.9%) and tumor-derived cell
lines (12/15, 80.0%). Moreover, targeted inhibition of livin by RNAi markedly sensitized RCC cells towards proapoptotic stimuli, such as UV irradiation or the chemotherapeutic drugs
etoposide, 5-fluorouracil, and vinblastine. These effects were specific for livin expressing tumor cells. We conclude that livin can contribute significantly to the apoptosis resistance of RCC cells. Targeted inhibition of livin could represent a novel therapeutic strategy to increase the sensitivity of renal cancers towards pro-apoptotic agents.
Received 30 November 2006; received after revision 22 February 2007; accepted 20 March 2007 相似文献
96.
97.
In October 1924, The Physical Review, a relatively minor journal at the time, published a remarkable two-part paper by John H. Van Vleck, working in virtual isolation
at the University of Minnesota. Using Bohr’s correspondence principle and Einstein’s quantum theory of radiation along with
advanced techniques from classical mechanics, Van Vleck showed that quantum formulae for emission, absorption, and dispersion
of radiation merge with their classical counterparts in the limit of high quantum numbers. For modern readers Van Vleck’s
paper is much easier to follow than the famous paper by Kramers and Heisenberg on dispersion theory, which covers similar
terrain and is widely credited to have led directly to Heisenberg’s Umdeutung paper. This makes Van Vleck’s paper extremely valuable for the reconstruction of the genesis of matrix mechanics. It also
makes it tempting to ask why Van Vleck did not take the next step and develop matrix mechanics himself.
This paper was written as part of a joint project in the history of quantum physics of the Max Planck Institut für Wissenschaftsgeschichte and the Fritz-Haber-Institut in Berlin. 相似文献
98.
DING Mingtao WEI Fangqiang ZHANG Jinghong WANG Hongjuan 《武汉大学学报:自然科学英文版》2007,12(4):599-604
By analyzing the observation data from Dongchuan Debris Flow Observation and Research Station and historical data from year 1965 to 1990 gotten from National Astronomical Ob-servatories/Yunnan Observatory,the responding of debris flow in Jiangjia Ravine to Solar Proton Flare is studied. The following conclusion can be drawn. Solar Proton Flare,as one of most im-portant astronomical factors,affects the activity of debris flow in Yunnan. Generally,from 1965 to1990,the more active Solar Pro-ton Flare is,the greater the probability of high frequency and large runoff of debris flow is. On the contrary,the less active Solar Pro-ton Flare is,the greater the probability of low frequency,small runoff,and low sediment transport of debris flow is. 相似文献
99.
Sobacchi C Frattini A Guerrini MM Abinun M Pangrazio A Susani L Bredius R Mancini G Cant A Bishop N Grabowski P Del Fattore A Messina C Errigo G Coxon FP Scott DI Teti A Rogers MJ Vezzoni P Villa A Helfrich MH 《Nature genetics》2007,39(8):960-962
Autosomal recessive osteopetrosis is usually associated with normal or elevated numbers of nonfunctional osteoclasts. Here we report mutations in the gene encoding RANKL (receptor activator of nuclear factor-KB ligand) in six individuals with autosomal recessive osteopetrosis whose bone biopsy specimens lacked osteoclasts. These individuals did not show any obvious defects in immunological parameters and could not be cured by hematopoietic stem cell transplantation; however, exogenous RANKL induced formation of functional osteoclasts from their monocytes, suggesting that they could, theoretically, benefit from exogenous RANKL administration. 相似文献
100.
Kitamura T Kometani K Hashida H Matsunaga A Miyoshi H Hosogi H Aoki M Oshima M Hattori M Takabayashi A Minato N Taketo MM 《Nature genetics》2007,39(4):467-475
Inactivation of TGF-beta family signaling is implicated in colorectal tumor progression. Using cis-Apc(+/Delta716) Smad4(+/-) mutant mice (referred to as cis-Apc/Smad4), a model of invasive colorectal cancer in which TGF-beta family signaling is blocked, we show here that a new type of immature myeloid cell (iMC) is recruited from the bone marrow to the tumor invasion front. These CD34(+) iMCs express the matrix metalloproteinases MMP9 and MMP2 and the CC-chemokine receptor 1 (CCR1) and migrate toward the CCR1 ligand CCL9. In adenocarcinomas, expression of CCL9 is increased in the tumor epithelium. By deleting Ccr1 in the background of the cis-Apc/Smad4 mutant, we further show that lack of CCR1 prevents accumulation of CD34(+) iMCs at the invasion front and suppresses tumor invasion. These results indicate that loss of transforming growth factor-beta family signaling in tumor epithelium causes accumulation of iMCs that promote tumor invasion. 相似文献